Sue Marshall blogs about diabetes for Desang

Diabete-ezy tips from Oz

August 19, 2010
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Another website run by people who live with diabetes who have got up and done something about it. This family has 3 kids and one parent with Type 1. they have their own version of a kitbag, pump belt and record book and some test wipes so you have super clean skin before you test to avoid dodgy readings. www.diabete-ezy.com

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Texas Researcher Poised to Test Leptin as a Replacement for Insulin Among Type 1s

April 23, 2010
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After mice “thrived” on the insulin-free regimen the hormone leptin offered, researchers are now ready to test the response on humans…

A University of Texas researcher who genetically modified mice with type 1 diabetes to control their disease with leptin instead of insulin is now ready to extend his experiment to human test subjects. Dr. Roger Unger, a researcher at the UT Southwestern Medical School in Dallas, will begin the tests as soon as leptin manufacturers can assure him of a steady supply of the hormone.

While other studies have indicated that the hormone may help control blood sugar levels, Unger and his associates were the first to experiment with leptin as a monotherapy in diabetes.

In his paper, “Leptin monotherapy in insulin dependent type 1 diabetes,” just published in the Proceedings of the National Academy of Sciences, Unger details how his team initially genetically modified diabetic mice to produce extra quantities of leptin. The mice were then taken off insulin and left to rely solely on leptin to control their blood sugar levels.

Unger reports that the mice thrived on the insulin-free regimen. Because genetic manipulation is not an option in human test subjects, the next step was to treat diabetic mice that had not been genetically altered with pump-delivered injections of leptin. Unger reports that those mice, too, did well despite the absence of insulin.

One reason for Unger’s desire to see if leptin can be a viable alternative to insulin is concern about the side effects produced by the typically large doses of insulin that most people with type 1 diabetes have to take. Among them are large fluctuations in blood sugar levels and possible long-term ill effects on blood vessels. In his experiments with leptin, Unger found that only low doses of the hormone were needed to maintain stable blood sugar levels.

Even as he undertakes tests with human subjects, Unger agrees with other diabetes experts that there is still a long way to go before leptin could be recommended as an alternative diabetes therapy. One important question the research may help answer is why leptin mimics insulin’s ability to deliver sugar to muscles and fat cells.

In comments on his paper, Dr. Barbara Kahn, a diabetes expert at Harvard Medical School and chief of endocrinology at Beth Israel Deaconess Medical Center in Boston, said that Unger’s research will have to address several other crucial questions:

  • Mouse and human eating patterns are very different. Mice graze constantly on food that takes a long time to digest, while humans eat several meals a day. Can leptin, which can maintain constant blood sugar levels in animals whose eating patterns do not create wide swings in the first place, work in humans, whose eating patterns invite such swings?
  • Unger’s mice had to be genetically altered to produce leptin, whereas most people with type 1 diabetes already produce normal amounts of leptin. What side effects might be created if the amount of leptin in their systems is increased?
  • Will leptin make it harder for type 1s to tell if they are having a hypoglycemic episode?

Whatever answers Unger’s further research delivers, they probably won’t help people with type 2 diabetes, who are resistant to both insulin and leptin.

via: Texas Researcher Poised to Test Leptin as a Replacement for Insulin Among Type 1s


Instructions Not Included

February 15, 2010
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Just found another blogger who is getting freaky about diabetes kit — and why not? We’ve got to use the stuff all the time. Might as well like it!

“I can see myself getting more and more keen to own the latest diabetes related gadgets. Words cannot describe how thrilled I was at the arrival of my super-sexy new PURPLE Asencia Contour meter came. It had a new finger pricker! It had an adjustable alarm! It had 7, 14 and 30 day averages! I could set my own high and low targets. I was in love. It did mean I had to give up my old pink meter wallet, but since that was fairly blood stained by now, I wasn’t too heartbroken. After all, this thing was purple! Thank you Bayer Diabetes.”

via Instructions Not Included.


Testing Blood Sugar Through Your Tears | Diabetes News Hound

January 11, 2010
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Researchers in Canada have developed a novel method that may one day be used to monitor the blood sugar of diabetics: contact lenses.

The contact lenses will continuously monitor blood sugar levels and alert the user that their sugar levels are off by changing color, according to an article published recently in the Times of India. The lenses are made of hydrogel and use very small nano-particles that react with glucose particles found in tears to measure the blood sugar levels.

Details of the lenses and their accuracy at measuring high and low blood sugars are limited, but the article notes that researchers are currently working to improve the technologies.

via Testing Blood Sugar Through Your Tears | Diabetes News Hound.


Researchers Question Benefit of Test Strips for Type 2 Patients | Diabetes News Hound

December 30, 2009
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Two new studies are suggesting that finger sticks and daily blood sugar monitoring is unnecessary and costly for the majority of Type 2 diabetics, according to a recent article published on the CTV Toronto website. However, for people with Type 1 diabetes, who rely on insulin injections to regulate their blood sugar levels, and people with Type 2 diabetes that also take insulin shots, test strips are a necessary and important tool.

via Researchers Question Benefit of Test Strips for Type 2 Patients | Diabetes News Hound.


Rethinking Carb Counting, Aggressive Blood Sugar Control | Diabetes News Hound

December 22, 2009
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Two practices that were commonly thought to be mainstays of diabetes control – carb counting and aggressive blood sugar control — are getting a second look.

via Rethinking Carb Counting, Aggressive Blood Sugar Control | Diabetes News Hound.


Vinegar may help control diabetes by lowering sugar levels

November 30, 2009
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People who are suffering from diabetes and have a tendency of spiking their blood sugar levels immediately after a meal should seriously think of adding a drop of vinegar in their meals.

via Vinegar may help control diabetes by lowering sugar levels.


Discussion: JDRF (Juvenile Diabetes Research Foundation) | LinkedIn

November 23, 2009
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Tiny tattoos could help diabetics ditch needles — fascinting and exciting story about a high-tech tattoo that uses nanospheres with an ink inside that reacts with glucose.

via Discussion: JDRF (Juvenile Diabetes Research Foundation) | LinkedIn.


diabetes planner! « In Search Of Balance

November 20, 2009
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I love being part of a community of people (diabetics) so many of whom face up to a daily problem by coming up with a solution. For some of us it’s kitbags, for some of us it’s memory aides (‘did I take my last injection?’) and for some of us it’s diaries. Here’s another one where Beth has come up with a diary/planner to suit her needs and just gets it printed on lulu.com

diabetes planner! « In Search Of Balance.


Free Bayer Blood Glucose Meter – Contour

November 20, 2009
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If you fancy trying out a different blood test machine, you can win a freebie Bayer Contour here. No coding required.

Free Bayer Blood Glucose Meter – Contour.


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